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Emmanuel N. Pitsinos, PhD
Research Director
Institute of Physical Chemistry, NCSR “DEMOKRITOS”
Laboratory of Natural Products Synthesis & Bioorganic Chemistry
P.O. Box 60228, GR 15310 Aghia Paraskevi, Greece
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Personal data
Date and place of birth: 23/10/1966, Greece
Telephone number: +30-2106503789
FAX number: +30-2106511766
E-Mail: pitsinos"at"chem.demokritos.gr
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Research Interests / Areas of Expertise
Synthetic Organic Chemistry
Bioorganic Chemistry
Natural Products Chemistry
Chemical Biology
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Education
1984 – 1988 B.Sc. (Chemistry), University of Thessaloniki, Greece
1989 – 1994 M.Sc., Ph.D., University of California, San Diego (UCSD), USA
Professional Track Record
1988 – 1989 Research Assistant, Department of Chemistry, University of Crete
1989 – 1994 Teaching Assistant, UCSD,Research Assistant, UCSD / The Scripps Research Institute, Prof. K.C. Nicolaou
1994 –1996 Military Service (obligatory).
1996 – 1997 Researcher D level, NCSR “DEMOKRITOS”, Inst. of Physical Chemistry
1997 – 1999 Marie Curie Fellow, Université Louis Pasteur, France, Prof. Jean-Marie Lehn
1999 – to date Researcher, NCSR “DEMOKRITOS”, Inst. of Physical Chemistry, Natural Products Synthesis & Bioorganic Chemistry Laboratory
Selected Publications (Total: 38 research articles, 6 patents; H-index = 17)
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Smith, A.L.; Hwang, C.-K.; Pitsinos, E.; Scarlato, G.R.; Nicolaou, K.C. “Enantioselective total synthesis of (–)-calicheamicinone” J. Am. Chem. Soc. 1992, 114, 3134–3136.
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Nicolaou, K.C.; Guy, R.K.; Pitsinos, E.N.; Wrasidlo, W. “A water-soluble prodrug of Taxol with self-assembling properties” Angew. Chem. Int. Ed. 1994, 33, 1583–1587.
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Nicolaou, K.C.; Vassilikogiannakis, G.; Simonsen, K.B.; Baran, P.S.; Zhong, Y.-L.; Vidali, V.P.; Pitsinos, E.N.; Couladouros, E.A. “Biomimetic total synthesis of Bisorbicillinol, Bisorbibutenolide, Trichodimerol, and designed analogues of Bisorbicillinoids” J. Am. Chem. Soc. 2000, 122, 3071–3079.
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Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A. “An expedient asymmetric synthesis of a calystegin B4 analogue” Synthesis 2002, 1707–1710.
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Couladouros, E.A.; Pitsinos, E.N.; Moutsos, V.I.; Sarakinos, G. “A general method for the synthesis of Bastaranes and Isobastaranes. First total synthesis of Bastadins 5, 10, 12, 16, 20 and 21” Chem. Eur. J. 2005, 11(1), 406–421.
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Pitsinos, E.N.; Cruz, A. “Short and efficient route to the fully functionalized core of Scyphostatin” Org. Lett. 2005, 7(11), 2245–2248.
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Wascholowski, V.; Giannis, A.; Pitsinos, E.N. “Influence of the scyphostatin side-chain on the mode of inhibition of neutral sphingomyelinase” ChemMedChem 2006, 1, 718–721.
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Pitsinos, E.N.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E.-I. "Total synthesis of (+)-Scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)" Chem. Commun. 2010, 46, 2200-2202.
Memberships
Greek Chemists Association, American Chemical Society, Marie Curie Fellows Association, The Sphingolipid Club, MC member of COST Action CM0602: Inhibitors of angiogenesis: design, synthesis and biological exploitation (ANGIOKEM) and COST Action CM0804: Chemical Biology with Natural Products.
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