Natural Products Synthesis & Bioorganic Chemistry |
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Written by Pitsinos M.
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Wednesday, 06 May 2009 10:18 |
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The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products Papageorgiou, V.P.; Assimopoulou, A.N.; Couladouros, E.A.; Hepworth, D.; Nicolaou, K. C. Angew. Chem. Int. Ed. 1999, 38, 270–300
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1,4-Reductive Addition of Hydrazoic Acid to g-Oxo-a,b-unsaturated d-Lactones and -Lactams: A Convenient Route to a-Amino-g-oxo-a,b-unsaturated d-Lactones and -Lactams Koulocheri, S.D.; Haroutounian, S.A.; Apostolopoulos, C.D.; Chada, R.K.; Couladouros E.A. Eur. J. Org. Chem. 1999, 1449–1453
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A General Synthetic Route Towards 7- and 8-Lactones. Total Asymmetric Synthesis of (–)-Muricatacin and the Mosquito Oviposition Pheromone (5R,6S)-6-Acetoxy-hexadecanolide Couladouros E.A.; Mihou, A.P. Tetrahedron Lett. 1999, 40, 4861–4862
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A general synthetic route towards bastadins. Part 2: Synthesis of the western part of bastadins 4-16, and fully functionalized macrocycle of bastadin 12 Couladouros E.A.; Moutsos, V.I. Tetrahedron Lett. 1999, 40, 7027–7030
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Biomimetic explorations towards the bisorbicillinoids. Total synthesis of bisorbicillinol, bisorbibutenolide and trichodimerol Nicolaou, K. C.; Simonsen, K. B.; Vassilikogiannakis, G.; Baran, P. S.; Vidali, V. P.; Pitsinos, E. N.; Couladouros, E. A. Angew. Chem. Int. Ed. 1999, 38, 3555–3559
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Biomimetic total synthesis of bisorbicillinol, bisorbibutenolide, trichodimerol, and designed analogues of bisorbicillinoids Nicolaou, K. C.; Vassilikogiannakis, G.; Simonsen, K. B.; Baran, P. S.; Zhong, Y.-L.; Vidali, V. P.; Pitsinos, E. N.; Couladouros, E. A. J. Am. Chem. Soc. 2000, 122, 3071–3079
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Heterofunctional linking agents for the synthesis of well-defined block copolymers of dimethylsiloxane and tert-butyl methacrylate or 2-vinylpyridine Bellas, V.; Iatrou, H.; Pitsinos, E.N.; Hadjichristidis, N. Macromolecules 2001, 34, 5376–5378
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A convenient route to alkaloid lipids: Application for the synthesis of a leptophylline A analogue Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A. Synthesis 2002, 111–115
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An expedient asymmetric synthesis of a calystegin B4 analogue Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A. Synthesis 2002, 1707–1710
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A novel 2΄-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models Wrasidlo, W.; Gaedicke, G.; Guy, R. K.; Renaud, J.; Pitsinos, E. N.; Nicolaou, K. C.; Reisfeld, R. A.; Lode, H. N. Bioconjugate Chemistry 2002, 13, 1093–1099
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A new efficient route for multigram asymmetric synthesis of alkannin and shikonin Couladouros, E. A.; Strongilos, A.T.; Papageorgiou, V.P.; Plyta, Z.F. Chem. Eur. J. 2002, 8, 1795–1803
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Synthetic studies towards trichodimerol and related vertinoid polyketides Pitsinos, E.N.; Vidali, V.P.; Couladouros, E.A. ARKIVOC 2002, 13, 105–110
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Photoresist etch resistance enhancement using novel polycarbocyclic derivatives as additives Gogolides, E.; Argitis, P.; Couladouros, E. A.; Vidali, V.P.; Vasilopoulou, M.; Cordoyannis, G.; Diakoumatos, C.D.; Tserepi, A. J. Vac. Sci. Technol. B 2003, 21, 141–147
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Synthesis and evaluation of three novel scyphostatin analogues as neutral sphingomyelinase inhibitors Pitsinos, E.N.; Wascholowski, V.; Karaliota, S.; Rigou, C.; Couladouros, E.A.; Giannis, A. ChemBioChem 2003, 4, 1223–1225
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Synthesis of o-brominated diaryl ethers using symmetrical iodonium salts: Application to the synthesis of Bastadin precursors Couladouros, E.A.; Moutsos, V.I.; Pitsinos, E.N. ARKIVOC 2003, 15, 92–101
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Novel Stereocontrolled Approach to syn- and anti-Oxepene-Cyclogeranyl trans-Fused Polycyclic Systems. Asymmetric Total Synthesis of (–)-Aplysistatin, (+)-Palisadin B, (+)-12-Hydroxy-Palisadin B and the AB Ring System of Adociasulfate-2 and Toxicol A Couladouros, E.A.; Vidali, V.P. Chem. Eur. J. 2004, 10, 3822-3835
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Synthetic studies towards oxazinins. An expedient first total synthesis and proof of the absolute stereochemistry of oxazinin-3 Couladouros, E.A.; Moutsos, V.I.; Pitsinos, E.N. Tetrahedron Lett. 2004, 45, 7779–7781
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First Total Synthesis of trans- and cis-Resorcylide Remarkable Hydrogen-Bond-Controlled Stereospecific Ring Closing Metathesis Couladouros E.A.; Mihou, A.P.; Bouzas E.A. Org. Lett. 2004, 6, 977–980
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A general method for the synthesis of bastaranes and isobastaranes. First total synthesis of bastadins 5, 10, 12, 16, 20 and 21 Couladouros, E.A.; Pitsinos, E.N.; Moutsos, V.I.; Sarakinos, G. Chem. Eur. J. 2005, 11, 406–421
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Oviposition responses of Culex pipiens to a synthetic racemic Culex quinquefasciatus oviposition aggregation pheromone Michaelakis, A.; Mihou, A.P.; Couladouros, E.A.; Zounos, A.K.; Koliopoulos, G. J. Agric. Food Chem. 2005, 53, 5225–5229
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Solid-phase total synthesis of (–)-Phenylhistine and (–)-Aurantiamine. Synthesis of a diverse dehydro-2,5-diketopiperazine library. Part II Couladouros, E.A., Magos, A.D. Molecular Diversity 2005, 9, 111–121
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Influence of the scyphostatin side-chain on the mode of inhibition of neutral sphingomyelinase Wascholowski, V.; Giannis, A.; Pitsinos, E.N. ChemMedChem 2006, 1, 718–721
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Oxazinins from toxic mussels: isolation of a novel oxazinin and reassignment of the C-2 configuration of oxazinin-1 and -2 on the basis of synthetic models Ciminiello, P.; Dell'Aversano, C.; Fattorusso, E.; Forino, M.; Magno, S.; Santelia, F.U.; Moutsos, V.I.; Pitsinos, E.N.; Couladouros, E.A. Tetrahedron 2006, 62, 7738–7743
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Synthetic bastadins modify the activity of ryanodine receptors in cultured cerebellar granule cells Ziemińska, E.; Stafiej, A.; Pitsinos, E.N.; Couladouros, E.A.; Moutsos, V.; Kozłowska, H.; Toczyłowska, B.; Łazarewicz, J.W. NeuroSignals 2006-07, 15, 283–292
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Stereo-structural determination of three novel oxazinins isolated from Adriatic mussels via a synthetic and NMR-based approach Ciminiello, P.; Dell’Aversano, C.; Fattorusso, E.; Forino, M.; Grauso, L.; Santelia, F.U.; Tartaglione, L.; Moutsos, V.I.; Pitsinos, E.N.; Couladouros, E.A. Eur. J. Org. Chem. 2007, 5434–5439
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Tumor necrosis factor-α promotes malignant pleural effusion Stathopoulos, G.T.; Kollintza, A.; Moschos, A.; Psallidas, I.; Sherrill, T.P.; Pitsinos, E.N.; Vassiliou, S.; Karatza, M.; Papiris, S.A.; Graf, D.; Orphanidou, D.; Light, R.W.; Roussos, C.; Blackwell, T.S.; Kalomenidis, I. Cancer Res. 2007, 67, 9825–9834
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Formal synthesis of the piperidine alkaloid (+/-)-prosophylline using polymer-supported dihydro-2H-pyridin-3-one Couladouros, E.A.; Strongilos, A.T.; Neokosmidis, E. Tetrahedron Lett. 2007, 48, 8227–8229
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Attract-and-kill strategy. Laboratory studies on hatched larvae of Culex pipiens Michaelakis, A.; Mihou, A.P.; Koliopoulos, G.; Couladouros, E.A. Pest Manag. Sci. 2007, 63, 954–959
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A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of b-, g-, and d-tocotrienols Couladouros, E.A.; Moutsos, V.I.; Lampropoulou, M.; Little, J.L.; Hyatt, J.A. J. Org. Chem. 2007, 72, 6735–6741
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Stochastic simulation studies of molecular resists Drygiannakis, D.; Patsis, G.P.; Raptis, I.; Niakoula, D.; Vidali, V.; Couladouros, E.; Argitis, P.; Gogolides, E. Microelectronic Engineering 2007, 84, 1062–1065
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Prolonged slow release of (Z)-11-hexadecenyl acetate employing polyurea microcapsules Mihou, A.P.; Michaelakis, A.; Krokos, F.D.; Mazomenos, B.E.; Couladouros, E.A. J. Appl. Entomol. 2007, 131, 128–133
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Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons Zieminska, E.; Lazarewicz, J.W.; Couladouros, E.A.; Moutsos,V.I.; Pitsinos, E.N. Bioorg. Med. Chem. Lett. 2008, 18, 5734–5737
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Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates Efthimiadou, E.K.; Katsarou,M.E.; Fardis, M.; Zikos, C.; Pitsinos, E.N.; Kazantzis, A.; Leondiadis, L.; Sagnou, M.; Vourloumis, D. Bioorg. Med. Chem. Lett. 2008, 18, 6058–6061
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Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens Michaelakis, A.; Strongilos, A.T.; Bouzas, E.A.; Koliopoulos, G.; Couladouros, E.A. Parasitol. Res. 2009, 104, 657–662
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Influence of the microencapsulated pheromone from aged infusion as an oviposition medium of the West Nile virus vector Culex pipiens Michaelakis, A.; Mihou, A.P.; Koliopoulos, G.; Couladouros, E.A. Parasitol. Res. 2009, 104, 1005–1009
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A short biomimetic approach to the fully functionalized bicyclic framework of type A acylphloroglucinols Couladouros, E.A.; Dakanali, M.; Demadis, K.D.; Vidali, V.P. Org. Lett. 2009, 11, 4430–4433
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Total synthesis of (+)-Scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA) Pitsinos, E.N.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E.-I. Chem. Commun. 2010, 46, 2200–2202
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Last Updated on Friday, 07 September 2012 09:12 |
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