Lectures / Seminars

    Prof. Thomas D. Anthopoulos 

    Department of Physics and Centre for Plastic Electronics, Imperial College London, Blackett Laboratory, London, UK

    in a lecture entitled:

    "New materials and fabrication paradigms for plastic electronics"

    Department of Advanced Materials auditorium (Building #8),

    Wednesday 20th of November 2013 at 11.a.m.


    Professor Rebecca Deprez - Poulain Pr PhD MRSC


    INSERM U761 Biostructures And Drug Discovery


    Universite De Lille 2 - Pasteur Institute Lille


    “Hydroxamates as tools for the target validation of metalloproteases:

    Applications To malarial PfAM1 And human Insulin-Degrading Enzyme”


    Wednesday 30rd of October at 12:00 pm,


    IPC auditorium


    The lecture is organized by the Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety (I.N.RA.S.T.E.S.) and Dr. E. Stratikos


    29/07/2013 Opening For a PhD studentship (Greek Version)



    17/01/2014 Opening For an Experienced Researcher/Fellow for MARIE CURIE SANAD project

    29/07/2013 Opening For a PhD studentship (Greek Version)

    15/07/2012 Opening For a PhD studentship

    15/07/2012 Opening For Post Doctoral Position

    06/06/2012 Opening For Synthetic Chemistry Post Doctoral Associate

    06/06/2012 Opening For Post Doctoral Associate on Carbon Nanomaterials

    06/06/2012 Opening For Synthetic Chemistry PhD Studentship


    Intenational Workshop | 31 October - 3 November 2011
    Macromolecular crystal growth and optimisation methods

    Workshop Program



    Photochemistry and Applications in Photoactivable Anticancer Drugs

    Bologna, September 26 – 28, 2011



    October 11 of 2010 :

    The Institute of Physical Chemistry actively participates in the establishment of the European Photocatalysis Federation and the coordination of the corresponding research activities in Greece.



    The 6th Summer School on Methods in Micro-Nanotechnology and Nanobiotechnology will be held in Athens, Greece September 13 - 17, 2010.  

    The Summer School is co-organized by the Institutes of Physical Chemistry, Microelectronics,  Radioisotopes & Radiodiagnostic Products and Materials Science,  NCSR Demokritos, in collaboration with the Foundation for Biomedical Research of the Academy of Athens.

    The Summer School  is co-sponsored by the project, Marie Curie ITN CYCLON  ( )  coordinated by the  Institute of Physical Chemistry.

    Special Events


    Institute of Physical Chemistry

    Institute of Physical Chemistry

    Natural Products Synthesis & Bioorganic Chemistry PDF Print E-mail
    Written by Pitsinos M.   
    Wednesday, 06 May 2009 10:18
    1. The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products
      Papageorgiou, V.P.; Assimopoulou, A.N.; Couladouros, E.A.; Hepworth, D.; Nicolaou, K. C.
      Angew. Chem. Int. Ed. 1999, 38, 270300
    2. 1,4-Reductive Addition of Hydrazoic Acid to g-Oxo-a,b-unsaturated d-Lactones and -Lactams: A Convenient Route to a-Amino-g-oxo-a,b-unsaturated d-Lactones and -Lactams
      Koulocheri, S.D.; Haroutounian, S.A.; Apostolopoulos, C.D.; Chada, R.K.; Couladouros E.A.
      Eur. J. Org. Chem. 1999, 14491453
    3. A General Synthetic Route Towards 7- and 8-Lactones. Total Asymmetric Synthesis of ()-Muricatacin and the Mosquito Oviposition Pheromone (5R,6S)-6-Acetoxy-hexadecanolide
      Couladouros E.A.; Mihou, A.P.
      Tetrahedron Lett. 1999, 40, 48614862
    4. A general synthetic route towards bastadins. Part 1: Synthesis of the eastern part of bastadins 4–16
      Couladouros E.A.; Moutsos, V.I.
      Tetrahedron Lett. 1999, 40, 70237026
    5. A general synthetic route towards bastadins. Part 2: Synthesis of the western part of bastadins 4-16, and fully functionalized macrocycle of bastadin 12
      Couladouros E.A.; Moutsos, V.I.
      Tetrahedron Lett. 1999, 40, 70277030
    6. Stabilization of microtubules by combretastatin D derivatives
      Couladouros, E. A.; Li, T.; Moutsos, V. I.; Pitsinos, E. N.; Soufli, I. C.
      Bioorg. Med. Chem. Lett. 1999, 9, 2927–2928
    7. Biomimetic explorations towards the bisorbicillinoids. Total synthesis of bisorbicillinol, bisorbibutenolide and trichodimerol
      Nicolaou, K. C.; Simonsen, K. B.; Vassilikogiannakis, G.; Baran, P. S.; Vidali, V. P.; Pitsinos, E. N.; Couladouros, E. A.
      Angew. Chem. Int. Ed. 1999, 38, 3555–3559
    8. Regioselective oxidation of 3-monosubstituted juglone derivatives
      Couladouros, E. A.; Strongilos, A.T.
      Tetrahedron Lett. 2000, 41, 535538
    9. Biomimetic total synthesis of bisorbicillinol, bisorbibutenolide, trichodimerol, and designed analogues of bisorbicillinoids
      Nicolaou, K. C.; Vassilikogiannakis, G.; Simonsen, K. B.; Baran, P. S.; Zhong, Y.-L.; Vidali, V. P.; Pitsinos, E. N.; Couladouros, E. A.
      J. Am. Chem. Soc. 2000, 122, 3071–3079
    10. Liquid crystals resulting from combined ionic and hydrogen bonding interactions of nucleobase derivatives
      Tsiourvas, D.; Mihou, A.P.; Couladouros, E. A.; Paleos, C.M.
      Mol. Cryst. Liq. Cryst. 2001, 362, 177184
    11. Vicinal tetraamines of defined geometry: Potential scaffolds for assembly
      Pitsinos, E.N.; Lehn, J.-M.; De Cian, A.
      Helv. Chim. Acta 2001, 84, 2231
    12. Heterofunctional linking agents for the synthesis of well-defined block copolymers of dimethylsiloxane and tert-butyl methacrylate or 2-vinylpyridine
      Bellas, V.; Iatrou, H.; Pitsinos, E.N.; Hadjichristidis, N.
      Macromolecules 2001, 34, 5376–5378
    13. A convenient route to alkaloid lipids: Application for the synthesis of a leptophylline A analogue
      Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A.
      Synthesis 2002, 111–115
    14. An expedient asymmetric synthesis of a calystegin B4 analogue
      Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A.
      Synthesis 2002, 1707–1710
    15. A novel 2΄-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models
      Wrasidlo, W.; Gaedicke, G.; Guy, R. K.; Renaud, J.; Pitsinos, E. N.; Nicolaou, K. C.; Reisfeld, R. A.; Lode, H. N.
      Bioconjugate Chemistry 2002, 13, 1093–1099
    16. A new efficient route for multigram asymmetric synthesis of alkannin and shikonin
      Couladouros, E. A.; Strongilos, A.T.; Papageorgiou, V.P.; Plyta, Z.F.
      Chem. Eur. J. 2002, 8, 17951803
    17. Synthesis of hydroxylated naphthoquinone derivatives
      Couladouros, E. A.; Strongilos, A.T.
      Eur. J. Org. Chem. 2002, 33413350
    18. Generation of libraries of pharmacophoric structures with increased complexity and diversity by employing polymorphic scaffolds
      Couladouros, E. A.; Strongilos, A.T.
      Angew. Chem. Int. Ed. 2002, 41, 36773680
    19. Synthetic studies towards trichodimerol and related vertinoid polyketides
      Pitsinos, E.N.; Vidali, V.P.; Couladouros, E.A.
      ARKIVOC 2002, 13, 105–110
    20. Photoresist etch resistance enhancement using novel polycarbocyclic derivatives as additives
      Gogolides, E.; Argitis, P.; Couladouros, E. A.; Vidali, V.P.; Vasilopoulou, M.; Cordoyannis, G.; Diakoumatos, C.D.; Tserepi, A.
      J. Vac. Sci. Technol. B 2003, 21, 141147
    21. Synthesis and evaluation of three novel scyphostatin analogues as neutral sphingomyelinase inhibitors
      Pitsinos, E.N.; Wascholowski, V.; Karaliota, S.; Rigou, C.; Couladouros, E.A.; Giannis, A.
      ChemBioChem 2003, 4, 1223–1225
    22. Synthesis of o-brominated diaryl ethers using symmetrical iodonium salts: Application to the synthesis of Bastadin precursors
      Couladouros, E.A.; Moutsos, V.I.; Pitsinos, E.N.
      ARKIVOC 2003, 15, 92–101
    23. Novel Stereocontrolled Approach to syn- and anti-Oxepene-Cyclogeranyl trans-Fused Polycyclic Systems. Asymmetric Total Synthesis of (–)-Aplysistatin, (+)-Palisadin B, (+)-12-Hydroxy-Palisadin B and the AB Ring System of Adociasulfate-2 and Toxicol A
      Couladouros, E.A.; Vidali, V.P.
      Chem. Eur. J. 2004, 10, 3822-3835
    24. Synthetic studies towards oxazinins. An expedient first total synthesis and proof of the absolute stereochemistry of oxazinin-3
      Couladouros, E.A.; Moutsos, V.I.; Pitsinos, E.N.
      Tetrahedron Lett. 2004, 45, 7779–7781
    25. First Total Synthesis of trans- and cis-Resorcylide Remarkable Hydrogen-Bond-Controlled Stereospecific Ring Closing Metathesis
      Couladouros E.A.; Mihou, A.P.; Bouzas E.A.
      Org. Lett. 2004, 6, 977980
    26. A general method for the synthesis of bastaranes and isobastaranes. First total synthesis of bastadins 5, 10, 12, 16, 20 and 21
      Couladouros, E.A.; Pitsinos, E.N.; Moutsos, V.I.; Sarakinos, G.
      Chem. Eur. J. 2005, 11, 406–421
    27. Short and efficient route to the fully functionalized core of scyphostatin
      Pitsinos, E.N.; Cruz, A.
      Org. Lett. 2005, 7, 2245–2248
    28. Synthesis and biological evaluation of novel steroid-modified ether phospholipids
      Karantonis, H.C.; Pitsinos, E.N.; Antonopoulou, S.; Couladouros, E.A.; Demopoulos, C.A.
      Chemistry and Physics of Lipids 2005, 138, 12–19
    29. Oviposition responses of Culex pipiens to a synthetic racemic Culex quinquefasciatus oviposition aggregation pheromone
      Michaelakis, A.; Mihou, A.P.; Couladouros, E.A.; Zounos, A.K.; Koliopoulos, G.
      J. Agric. Food Chem. 2005, 53, 52255229
    30. Total asymmetric synthesis of (–)-Phenylhistine, (–)-Aurantiamine and related compounds. Part I
      Couladouros, E.A., Magos, A.D.
      Molecular Diversity 2005, 9, 99109
    31. Solid-phase total synthesis of (–)-Phenylhistine and (–)-Aurantiamine. Synthesis of a diverse dehydro-2,5-diketopiperazine library. Part II
      Couladouros, E.A., Magos, A.D.
      Molecular Diversity 2005, 9, 111121
    32. Influence of the scyphostatin side-chain on the mode of inhibition of neutral sphingomyelinase
      Wascholowski, V.; Giannis, A.; Pitsinos, E.N.
      ChemMedChem 2006, 1, 718–721
    33. Formal synthesis of Abyssomicin C
      Couladouros, E.A.; Bouzas, E.A.; Magos, A.D.
      Tetrahedron 2006, 62, 5272–5279
    34. Oxazinins from toxic mussels: isolation of a novel oxazinin and reassignment of the C-2 configuration of oxazinin-1 and -2 on the basis of synthetic models
      Ciminiello, P.; Dell'Aversano, C.; Fattorusso, E.; Forino, M.; Magno, S.; Santelia, F.U.; Moutsos, V.I.; Pitsinos, E.N.; Couladouros, E.A.
      Tetrahedron 2006, 62, 7738–7743
    35. Synthesis of enantiopure (S)-7-hydroxy-3-amino-3,4-dihydro-2H-1-benzopyran en route to (+)-scyphostatin
      Pitsinos, E.N.; Moutsos, V.I.; Vageli, O.
      Tetrahedron Lett. 2007, 48, 1523–1526
    36. Synthetic bastadins modify the activity of ryanodine receptors in cultured cerebellar granule cells
      Ziemińska, E.; Stafiej, A.; Pitsinos, E.N.; Couladouros, E.A.; Moutsos, V.; Kozłowska, H.; Toczyłowska, B.; Łazarewicz, J.W.
      NeuroSignals 2006-07, 15, 283–292
    37. Stereo-structural determination of three novel oxazinins isolated from Adriatic mussels via a synthetic and NMR-based approach
      Ciminiello, P.; Dell’Aversano, C.; Fattorusso, E.; Forino, M.; Grauso, L.; Santelia, F.U.; Tartaglione, L.; Moutsos, V.I.; Pitsinos, E.N.; Couladouros, E.A.
      Eur. J. Org. Chem. 2007, 5434–5439
    38. Tumor necrosis factor-α promotes malignant pleural effusion
      Stathopoulos, G.T.; Kollintza, A.; Moschos, A.; Psallidas, I.; Sherrill, T.P.; Pitsinos, E.N.; Vassiliou, S.; Karatza, M.; Papiris, S.A.; Graf, D.; Orphanidou, D.; Light, R.W.; Roussos, C.; Blackwell, T.S.; Kalomenidis, I.
      Cancer Res. 2007, 67, 9825–9834
    39. Formal synthesis of the piperidine alkaloid (+/-)-prosophylline using polymer-supported dihydro-2H-pyridin-3-one
      Couladouros, E.A.; Strongilos, A.T.; Neokosmidis, E.
      Tetrahedron Lett. 2007, 48, 82278229
    40. Attract-and-kill strategy. Laboratory studies on hatched larvae of Culex pipiens
      Michaelakis, A.; Mihou, A.P.; Koliopoulos, G.; Couladouros, E.A.
      Pest Manag. Sci. 2007, 63, 954959
    41. A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of b-, g-, and d-tocotrienols
      Couladouros, E.A.; Moutsos, V.I.; Lampropoulou, M.; Little, J.L.; Hyatt, J.A.
      J. Org. Chem. 2007, 72, 67356741
    42. Stochastic simulation studies of molecular resists
      Drygiannakis, D.; Patsis, G.P.; Raptis, I.; Niakoula, D.; Vidali, V.; Couladouros, E.; Argitis, P.; Gogolides, E.
      Microelectronic Engineering 2007, 84, 10621065
    43. Prolonged slow release of (Z)-11-hexadecenyl acetate employing polyurea microcapsules
      Mihou, A.P.; Michaelakis, A.; Krokos, F.D.; Mazomenos, B.E.; Couladouros, E.A.
      J. Appl. Entomol. 2007, 131, 128133
    44. Stereoselective syntheses of 2,6-disubstituted piperidin-3-oles (alkaloid lipids)
      Koulocheri, S.D.; Pitsinos, E.N.; Haroutounian, S.A.
      Current Organic Chemistry 2008, 12, 14541467
    45. Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons
      Zieminska, E.; Lazarewicz, J.W.; Couladouros, E.A.; Moutsos,V.I.; Pitsinos, E.N.

      Bioorg. Med. Chem. Lett. 2008, 18, 5734–5737 
    46. Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates
      Efthimiadou, E.K.; Katsarou,M.E.; Fardis, M.; Zikos, C.; Pitsinos, E.N.; Kazantzis, A.; Leondiadis, L.; Sagnou, M.; Vourloumis, D.
      Bioorg. Med. Chem. Lett. 2008, 18, 6058–6061
    47. Synthesis of novel laurenditerpenol analogues and their evaluation as HIF-1 activation inhibitors
      Athinaios, N; Kazantzis, A.; Putzker, K.; Lewis, J.; Pitsinos, E.N.
      Letters in Organic Chemistry 2009, 6, 269271
    48. Materials for lithography in the nanoscale
      Argitis, P.; Niakoula, D.; Douvas, A.M.; Gogolides, E.; Raptis, I.; Vidali, V.P.; Couladouros, E.A.
      International Journal of Nanotechnology 2009, 6, 71-87
    49. Larvicidal activity of naturally occurring naphthoquinones and derivatives against the West Nile virus vector Culex pipiens
      Michaelakis, A.; Strongilos, A.T.; Bouzas, E.A.; Koliopoulos, G.; Couladouros, E.A.
      Parasitol. Res. 2009, 104, 657–662
    50. Influence of the microencapsulated pheromone from aged infusion as an oviposition medium of the West Nile virus vector Culex pipiens
      Michaelakis, A.; Mihou, A.P.; Koliopoulos, G.; Couladouros, E.A.
      Parasitol. Res. 2009, 104, 1005–1009
    51. A short biomimetic approach to the fully functionalized bicyclic framework of type A acylphloroglucinols
      Couladouros, E.A.; Dakanali, M.; Demadis, K.D.; Vidali, V.P.
      Org. Lett. 2009, 11, 4430–4433
    52. Total synthesis of (+)-Scyphostatin featuring an enantioselective and highly efficient route to the side-chain via Zr-catalyzed asymmetric carboalumination of alkenes (ZACA)
      Pitsinos, E.N.; Athinaios, N.; Xu, Z.; Wang, G.; Negishi, E.-I.
      Chem. Commun. 2010, 46, 2200–2202
    53. Diaryl ether formation in the synthesis of natural products
      Pitsinos, E.N.; Vidali, V.P.; Couladouros, E.A.
      Eur. J. Org. Chem. 2011, 1207-1222
    54. Enantioselective total synthesis of (–)-laurenditerpenol
      Pitsinos, E.N.; Athinaios, N.; Vidali, V.P.
      Org. Lett. 2012, 14, 4666-4669
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