Publications

38.  A. Papakyriakou, D. Vourloumis, F. Tzortzatou-Stathopoulou, M. Karpusas, “Conformational dynamics of the EGFR kinase domain reveals structural features involved in activation.” Proteins 2009, in press. pdf

37.  E.K. Efthimiadou, M.E. Katsarou, M. Fardis, C. Zikos, E.N. Pitsinos, A. Kazantzis, L. Leondiadis, M. Sagnou, D. Vourloumis, “Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates.” Bioorg. Med. Chem. Lett. 2008, 18, 6058-6061. pdf

36.  M.E. Katsarou, Ε.Κ. Efthimiadou, G. Psomas, A. Karaliota, D. Vourloumis, “Novel Copper(II) Complex of N-Propyl-norfloxacin and 1,10-Phenanthroline with Enhanced Antileukemic and DNA Nuclease Activities”, J. Med. Chem. 2008, 51, 470-478. pdf

35.  Y. Zhou, V.E. Gregor, Z. Suyn, B.K. Ayida, G.C. Winters, D. Murphy, K.B. Simonsen, D. Vourloumis, S. Fish, J.M. Froelich, D. Wall, T. Hermann, “Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.” Antimicrob. Agents Chemother. 2005, 49, 4942–4949. pdf

34.  B. Ayida, K.B. Simonsen, D. Vourloumis, T. Hermann, “Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.” Bioorg. Med. Chem. Lett. 2005, 15, 2457–2460. pdf

33.  Q. Han, Q. Zhao, S. Shandrick, K.B. Simonsen, D. Vourloumis, J.M. Froelich, D. Wall, T. Hermann, “Molecular Recognition by Glycoside Pseudo Base Pairs and Triples in an Apramycin-RNA Complex.” Angew. Chem. Int. Ed. 2005, 44, 2694–2700. pdf

32.  D. Vourloumis, G.C. Winters, K.B. Simonsen, M. Takahashi, B. Ayida, S. Shandrick, Q. Zhao, Q. Han, T. Hermann, “Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site.” ChemBioChem 2005, 6, 58–65. pdf

31.  S. Shandrick, Q. Zhao, Q. Han, B. Ayida, M. Takahashi, G.C. Winters, K.B. Simonsen, D. Vourloumis, T. Hermann, “Monitoring Molecular Recognition of the Ribosomal Decoding Site.” Angew. Chem. Int. Ed. 2004, 43, 3177–3182. pdf

30.  K.C. Nicolaou, Y. Li, K. Sugita, H. Monenschein, P. Guntupalli, H.J. Mitchell, K.C. Fylaktakidou, D. Vourloumis, P. Giannakakou, A. O’Brate, “Total Synthesis of Apoptolidin: Completion of the Synthesis and Analogue Synthesis and Evaluation.” J. Am. Chem. Soc. 2003, 125, 15443–15454. pdf

29.  S. Barluenga, K.B. Simonsen, E. Littlefield, B. Ayida, D. Vourloumis, G.C. Winters, M. Takahashi, S. Shandrick, Q. Zhao, Q. Han, T. Hermann, “Rational Design of Azepane-Glycoside Antibiotics Targeting the Bacterial Ribosome.” Bioorg. Med. Chem. Lett. 2004, 14, 713–718. pdf

28.  K.B. Simonsen, B. Ayida, D. Vourloumis, G.C. Winters, M. Takahashi, S. Shandrick, Q. Zhao, T. Hermann, “Piperidine Glycosides Targeting the Ribosomal Decoding Site.” ChemBioChem 2003, 4, 886–890. pdf

27.  D. Vourloumis, G.C. Winters, M. Takahashi, K.B. Simonsen, B. Ayida, S. Shandrick, Q. Zhao, T. Hermann, “ Novel Acyclic Deoxystreptamine Mimetics Targeting the Ribosomal Decoding Site.” ChemBioChem 2003, 4, 879–885. pdf

26.  D. Vourloumis, M. Takahashi, K.B. Simonsen, B. Ayida, S. Barluenga, G.C. Winters, T. Hermann, “Solid phase synthesis of benzimidazole libraries biased for RNA-targets.” Tetrahedron Lett. 2003, 44, 2807–2811. pdf

25.  D. Vourloumis, M. Takahashi, G.C. Winters, K.B. Simonsen, B. Ayida, S. Barluenga, S. Qamar, S. Shandrick, Q. Zhao, T. Hermann, “ Novel 2,5-Dideoxystreptamine Derivatives Targeting the Ribosomal Decoding Site RNA.” Bioorg. Med. Chem. Lett. 2002, 12, 3367–3372. pdf

24.  K.B. Simonsen, B. Ayida, D. Vourloumis, M. Takahashi, G.C. Winters, S. Barluenga, S. Qamar, S. Shandrick, Q. Zhao, T. Hermann, “ Novel Paromamine Derivatives Exploring Shallow Groove Recognition of Ribosomal Decoding Site RNA.” ChemBioChem 2002, 3, 1223–1228. pdf

23.  R.A. Newman, J. Yang, M.R.V. Finlay, F. Cabral, D. Vourloumis, C. Stevens, P. Troncoso, X. Wu, C.J. Logothetis, K.C. Nicolaou, N.M. Navone, “Antitumor Efficacy of 26-Fluoroepothilone B Against Human Prostate Cancer Xenografts.” Cancer Chemother. Pharmacol. 2001, 48, 319–326. pdf

22.  K.C. Nicolaou, D. Vourloumis, N. Winssinger, P.S. Baran, "The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century." Angew. Chem. Int. Ed. 2000, 39, 44–122. pdf cover

21.  K.C. Nicolaou, J. Pfefferkorn, J. Xu, N. Winssinger, T. Ohshima, S. Kim, S. Hosokawa, D. Vourloumis, F. Van Delft, T. Li, "Total Synthesis and Chemical Biology of the Sarcodictyins." Chem. Pharm. Bull. 1999, 47, 1199–1213.

20.  E. Hamel, D.L. Sackett, D. Vourloumis, K.C. Nicolaou, "The Coral-Derived Natural Products Eleutherobin and Sarcodictyins A and B: Effects on the Assembly of Purified Tubulin with and without Microtubule-Associated Proteins and Binding at the Polymer Taxoid Site." Biochemistry 1999, 38, 5490–5498. pdf

19.  K.C. Nicolaou, N. Winssinger, D. Vourloumis, T. Ohshima, S. Kim, J. Pfefferkorn, J.-Y. Xu, T. Li, "Solid and Solution Phase Synthesis and Biological Evaluation of Combinatorial Sarcodictyin Libraries." J. Am. Chem. Soc. 1998, 120, 10814–10826. pdf

18.  K.C. Nicolaou, T. Ohshima, S. Hosokawa, F. van Delft, D. Vourloumis, J.-Y. Xu, J. Pfefferkorn, S. Kim, "Total Synthesis of Eleutherobin and Eleuthosides A and B." J. Am. Chem. Soc. 1998, 120, 8674–8680. pdf

17.  K.C. Nicolaou, J.-Y. Xu, J. Pfefferkorn, T. Ohshima, D. Vourloumis, S. Hosokawa, "Total Synthesis of Sarcodictyins A and B." J. Am. Chem. Soc. 1998, 120, 8661–8673. pdf

16.  K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, F. Sarabia, S. Ninkovic, D. Hepworth, "Total Synthesis of Epothilone E and Related Side Chain Modified Analogues via a Stille Coupling Based Strategy." Bioorg. Med. Chem. 1999, 7, 665–697. pdf

15.  K.C. Nicolaou, M.R.V. Finlay, S. Ninkovic, N.P. King, Y. He, T. Li, F. Sarabia, D. Vourloumis, "Synthesis and Biological Properties of C12,13-Cyclopropyl-Epothilone A and Related Epothilones." Chem. & Biol. 1998, 5, 365–372. pdf

14.  K.C. Nicolaou, S. Kim, J. Pfefferkorn, J.-Y. Xu, T. Ohshima, S. Hosokawa, D. Vourloumis, T. Li, "Chemical Synthesis and Biology of Sarcodictyins." Angew. Chem. Int. Ed. 1998, 37, 1418–1421. pdf

13.  K.C. Nicolaou, F. Roschangar, D. Vourloumis, "Chemical Biology of Epothilones." Angew. Chem. Int. Ed. 1998, 37, 2014–2045. pdf cover

12.  K.C. Nicolaou, F. van Delft, T. Ohshima, D. Vourloumis, J. Xu, S. Hosokawa, J. Pfefferkorn, S. Kim, T. Li, "Total Synthesis of Eleutherobin." Angew. Chem. Int. Ed. Engl. 1997, 36, 2520–2524. pdf

11.  K.C. Nicolaou, Y. He, F. Roschangar, N.P. King, D. Vourloumis, T. Li, "Total Synthesis of Epothilone E and Analogues with Modified Side Chains through the Stille Coupling Reaction." Angew. Chem. Int. Ed. 1998, 37, 84–87. pdf

10.  K.C. Nicolaou, D. Vourloumis, T. Li, J. Pastor, N. Winssinger, Y. He, S. Ninkovic, F. Sarabia, H. Vallberg, F. Roschangar, N.P. King, M.R.V. Finlay, P. Giannakakou, P. Verdier-Pinard, E. Hamel, "Designed Epothilones: Solid Phase Synthesis on Microtubes, Tubulin Assembly Properties and Cytotoxic Action Against Taxol-Resistant Tumor Cells." Angew. Chem. Int. Ed. Engl. 1997, 36, 2097–2103. pdf

9.  K.C. Nicolaou, F. Sarabia, M.R.V. Finlay, S. Ninkovic, N.P. King, D. Vourloumis, Y. He, “Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone B Analogues by the Macrolactonization Approach." Chem. Eur. J. 1997, 3, 1971–1986. pdf

8.  K.C. Nicolaou, H. Vallberg, N.P. King, F. Roschangar, Y. He, D. Vourloumis, C.G. Nicolaou, "Total Synthesis of Oxazole- and Cyclopropane-Containing Epothilone A Analogues by the Olefin Metathesis Approach." Chem. Eur. J. 1997, 3, 1957–1970. pdf

7.  K.C. Nicolaou, S. Ninkovic, F. Sarabia, D. Vourloumis, Y.He, H. Vallberg, Z. Yang, "Total Synthesis of Epothilones A and B via a Macrolactonization Based Strategy." J. Am. Chem. Soc. 1997, 119, 7974–7991. pdf

6.  K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, F. Roschangar, F. Sarabia, S. Ninkovic, Z. Yang, J.I. Trujillo, "The Olefin Metathesis Approach to Epothilone A and Its Analogs." J. Am. Chem. Soc. 1997, 119, 7960–7973. pdf

5.  K.C. Nicolaou, N. Winssinger, J. Pastor, S. Ninkovic, F. Sarabia, Y. He, D. Vourloumis, Z. Yang, T. Li, P. Giannakakou, E. Hamel, "Synthesis of Epothilones A and B in Solid and Solution Phase." Nature 1997, 387, 268–272. pdf

4.  Z. Yang, Y. He, D. Vourloumis, H. Vallberg, K.C. Nicolaou,"Total Synthesis of Epothilone A: The Olefin Metathesis Approach." Angew. Chem. Int. Ed. Engl. 1997, 36, 166–168. pdf

3.  K.C. Nicolaou, Y. He, D. Vourloumis, H. Vallberg, Z. Yang, "An Approach to Epothilones Based on Olefin Metathesis." Angew. Chem. Int. Ed. Engl. 1996, 35, 2399–2401. pdf

2.  D. Vourloumis, K.D. Kim, J.L. Petersen, P.A. Magriotis, "Cobalt-Assisted Claisen Rearrangement of Enediyne Lactones at Ambient Temperature. Studies toward a Synthetic Application of the Myers Cycloaromatization." J. Org. Chem. 1996, 61, 4848–4852. pdf

1.  P.A. Magriotis, D. Vourloumis, M.E. Scott, A. Tarli, "Novel Generation of Conjugated Alkynyl Ketenes. Efficient Synthesis of b,g-Alkynyl Lactones." Tetrahedron Lett. 1993, 34, 2071–2074. pdf

Patents

16.  D. Vourloumis, D.E. Murphy, T.J. Prins, F. Ruebsam, C.V. Tran, S.J. Berthel, R.F. Kester, R. “Oxime Glucokinase Activators.” U.S. Provisional Patent Application No. 23198 US (pending).

15.  K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, "Epothilone Analogs." US 7,173,137 B2, publication date: Feb. 6, 2007.

14.  D. Vourloumis, D.E. Murphy, T.J. Prins, F. Ruebsam, C.V. Tran, S.J. Berthel, R.F. Kester, R. Ramakanth, “Pyrazole Glucokinase Activators.” U.S. Provisional Patent Application No. 23161 US1 (pending).

13.  Y. Zhou, D. Vourloumis, V.E. Gregor, G.C. Winters, T. Hermann, B. Ayida, Z. Sun, D. Murphy, K.B. Simonsen, “ Antibacterial 3,5-Diaminopiperidine-Substituted Aromatic and Heteroaromatic Compounds.” WO 2005/028467 A1, international publication date: Mar 31, 2005.

12.  D. Vourloumis, M. Takahashi, G.C. Winters, J. Zhou, R. Duchene, “Heterocyclic Compounds for Treating Hepatitis C Virus.” WO 2004/110351 A2, international publication date: Dec 24, 2004.

11.   K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, "Epothilone Analogs." US 6,660,758 B1, publication date: Dec. 9, 2003.

10.  D. Vourloumis, “Hydrazone Compounds and Analogs Thereof for Treating Hepatitis C Virus.” U.S. Patent Application No. 60/470,200, filed May 14, 2003 (pending).

9.  D. Vourloumis, M. Takahashi, T. Hermann, “Tri-Substituted Benzimidazoles and Solid Phase Organic Synthesis Thereof.” Serial No. 60/428,976, filed November 26, 2002 (pending).

8.  K.C. Nicolaou, N Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, " Epothilone Analogs." US 6,441,186 B1, publication date: Aug. 27, 2002.

7.  K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, F. Sarabia, S. Ninkovic, D. Hepworth, T. Li, " Epothilone Analogs." US 6,380,394 B1. CAN 136:340536, publication date: Apr. 30, 2002.

6.  K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, "Epothilone Derivatives and Their Synthesis and Use" US 6,531,497 B1, publication date: Mar. 11, 2003.

5.  K.C. Nicolaou, N.P. King, M.R.V. Finlay, Y. He, F. Roschangar, D. Vourloumis, H. Vallberg, A. Bigot, "Epothilone Derivatives and Their Synthesis and Use" WO 99/67252, CAN 132:49831, international publication date: Dec. 29, 1999.

4.  K.C. Nicolaou, F. van Delft, S. Hosokawa, S. Kim, T. Li, T. Ohshima, J. Pfefferkorn, D. Vourloumis, J.-Y Xu, "Preparation of sarcodictyin and Eleutherobin and Analogs Useful for Stabilizing Microtubules." WO 99/21862, CAN 130:325273, international publication date: May 6, 1999.

3.  K.C. Nicolaou, F. van Delft, S. Hosokawa, S. Kim, T. Li, T. Ohshima, J. Pfefferkorn, D. Vourloumis, J.-Y Xu, N. Winssinger, "Analogs of Sarcodictyin and Eleutherobin." US 5,965,718. CAN 130:325273, publication date: Oct. 12, 1999.

2.  K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, "Epothilone Analogs." AU 1998/57577 B2, publication date: Jul. 03, 1998.

1.  K.C. Nicolaou, Y. He, S. Ninkovic, J. Pastor, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, N. Winssinger, Z. Yang, N.P. King, M.R.V. Finlay, "Preparation of Epothilone Analogs as Anticancer Agents." WO 98/25929, CAN 129:81625, international publication date: June 18, 1998.

Presentations

22.  Kythreoti Georgia, Zografos Alexandros L., Katsoulis Ioannis, Athanasios Papakyriakou, Anastasopoulou Panoula, Mavridis Ioannis, Vourloumis Dionisios* “Chemical Biology of Small Molecules Interfering with Protein-Synthesis”, XXth International Symposium on Medicinal Chemistry, Vienna, Austria, August 31 - September 4, 2008. Abstract published in Drugs of the Future 2008, 33, Suppl. A, P249.

21.  E. Efthimiadou, M. Katsarou, M. Fardis, C. Zikos, E.N. Pitsinos, A. Kazantzis, L. Leondiadis, D. Vourloumis* “New contrast agents exploiting natural products for targeted magnetic resonance imaging”, XX^th International Symposium on Medicinal Chemistry, Vienna, Austria, August 31 - September 4, 2008. Abstract published in Drugs of the Future 2008, 33, Suppl. A, P226. pdf

20.  E. Efthimiadou, M. Katsarou, M. Fardis, C. Zikos, E.N. Pitsinos, A. Kazantzis, L. Leondiadis, D. Vourloumis* “New contrast agents exploiting natural products for targeted magnetic resonance imaging”, 7^th Joint Meeting of AFERP, ASP, GA, PSE & SIF: Natural Products with Pharmaceutical, Nutraceutical, Cosmetic and Agrochemical interest, Athens, Greece, August 3 – 8, 2008. Book of Abstracts 2008, PG103. pdf

19.  Anastasopoulou Panoula, Zografos Alexandros L., Katsoulis Ioannis, Athanasios Papakyriakou, Kythreoti Georgia, Mavridis Ioannis, Vourloumis Dionisios* “Chemical Biology of Small Molecules Interfering with Protein-Synthesis”, BOSS XI, 11^th Belgian Organic Synthesis Symposium, Ghent, Belgium, July 13 - 18, 2008. Book of Abstracts 2008, P26.

18.  Dionisios Vourloumis et al. “Chemical Biology of Small Molecules Interfering with Protein-Synthesis” ESF-COST High-Level Research Conference: Natural Products Chemistry, speaker and session chair, Biology and Medicine, Acquafredda di Maratea, Italy, May 18–23, 2008. Book of Abstracts 2008, pages 60 – 61.

17.  Athanasios Papakyriakou and Dionisios Vourloumis “Rational Design of Vascular Endothelial Growth Factor Receptor-2 (VEGFR-2) Inhibitors based on Molecular Dynamics Simulations” 9^th International Conference in Medicinal Chemistry: Drug discovery and design, University of Patra, Greece, March 26–28, 2008. pdf

16.  Dionisios Vourloumis et al. “New Contrast Agents for Magnetic Resonance Imaging targeting Cancer Cells”, 2^nd price Award, 9^th International Conference in Medicinal Chemistry: Drug discovery and design, University of Patra, Greece, March 26–28, 2008. pdf

15.  Dionisios Vourloumis et al. “Chemical Biology of Small Molecules Interfering with Protein-Synthesis” 9^th International Conference in Medicinal Chemistry: Drug discovery and design, University of Patra, Greece, March 26–28, 2008.

14.  Dionisios Vourloumis, “Chemical Biology of Small Molecules Interfering with Protein-Synthesis” 13^th National Conference in Medicinal Chemistry, Athens, Greece, March 14–15, 2008.

13.  Dionisios Vourloumis, “RNA as a Drug Target: A Case Study” Nano2life Summer School on Methods in Micro-Nanotechnology and Nanobiotechnology, 2007, Athens, Greece, June 25 - July 6, 2007.

12.  Dionisios Vourloumis, “Targeting RNA with small molecules.” 2^nd Hellenic Symposium on Organic Synthesis, University of Athens, Invited speaker, Athens, Greece, April 19–21, 2007.

11.  Dionisios Vourloumis, “Targeting RNA with small molecules.” EMBO Conference on “Viral RNA: Structure, Function and Targeting”, Invited speaker, EMBL Heidelberg, Germany, March 5–7, 2007.

10.  Dionisios Vourloumis, “RNA as a Drug Target.” Summer School 2006, NCSR “Demokritos”, Athens, Greece, July 10–21, 2006.

9.  Dionisios Vourloumis, “RNA as a Drug Target: A Case Study” Nano2life Summer School on Methods in Micro-Nanotechnology and Nanobiotechnology, 2006, Athens, Greece, June 26 - July 7, 2006.

8.  Dionisios Vourloumis, “Targeting RNA with Small Molecules.” National Hellenic Research Foundation, Athens, Greece, June 6, 2006.

7.  Dionisios Vourloumis, “RNA as a Drug Target.” 12^th National Conference in Medicinal Chemistry, University of Patra, Greece, January 27–28, 2006.

6.  Dionisios Vourloumis, “Chemical Biology of the Epothilones.” University of Athens, Greece, March 2001.

5.  N. Winssinger, A. Bigot, M.R.V. Finlay, Y. He, D. Hepworth, S. Kim, N.P. King, T. Li, S. Ninkovic, T. Ohshima, J. Pastor, J. Pfefferkorn, F. Roschangar, F. Sarabia, H. Vallberg, D. Vourloumis, J.Y. Xu, Z. Yang, K.C. Nicolaou, “Epothilones and Sarcodictyins: From Combinatorial Libraries to Designed Analogs.” Book of Abstracts, 219^th ACS National Meeting, San Francisco, CA, March 26–30, 2000.

4.  Dionisios Vourloumis, “Chemical Biology of Tubulin Polymerizing Agents.” University of Crete, Greece, April 1999.

3.  Dionisios Vourloumis, “Chemical Biology of Tubulin Polymerizing Agents.” University of Athens, Greece, April 1999.

2.  Dionisios Vourloumis, “New Drugs Against Prostate and Other Cancers.” CaP CURE’s Fifth Annual Scientific Conference, Lake Tahoe, Nevada, September 1998.

1.  P.A. Magriotis, D. Vourloumis, M.E. Scott, A. Tarli, "Novel Generation of Conjugated Alkynyl Ketenes. Synthesis of b,g-Alkynyl Lactones." Book of Abstracts, 205th National ACS Meeting, Denver, CO, 1993. Selected among the 10 best scientific works of the Organic Division and presented at the SCIMIX of the same meeting